Since 2020, aggregated from related topics
Proteinase-activated receptor-2 (PAR2) is a member of the G-protein-coupled receptor family that is activated by proteolytic cleavage at a specific site on the receptor. PAR2 plays a role in various physiological processes, including inflammation, pain perception, and gastrointestinal function. Research in this area focuses on understanding the mechanisms of PAR2 activation, its downstream signaling pathways, and its involvement in different disease processes. Targeting PAR2 signaling pathways has the potential to lead to the development of novel therapeutic interventions for conditions such as inflammatory diseases, chronic pain, and cancer.